| Email : endangastuti@ugm.ac.id |
| Education Background : |
| Doctor, Dr, Kimia, Universitas Gadjah Mada, 2015 Master, M.Si, Kimia, Universitas Gadjah Mada, 2001 Undergraduate, Dra, Kimia, Universitas Gadjah Mada, 1992 |
| Research Interest : |
| Senyawa bioaktif dan enzim untuk pengembangan obat Aktif meneliti tentang kimia radikal bebas / kimia organik, serta kimia kedokteran dan biomolekuler dan obat. Berfokus pula pada penelitian mengenai molekul aktif biologis dan enzim untuk pengembangan obat. |
| Research Cluster/Group : |
| Medisinal, Bioteknologi, Sintesis, Bahan Alam |
| List of Publications : |
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(1) Wulan, F. F.; Pranaya, R. C.; Jecky; Nadira, I.; Astuti, E.; Prasetyo, N.; Wahyuningsih, T. D. Furanyl-Chalcones as Antimalarial Agent: Synthesis, in Vitro Study, DFT, and Docking Analysis of PfDHFR Inhibition. Pure Appl. Chem. 2025. https://doi.org/10.1515/pac-2024-0330. (2) Ghifari, T. A.; Wulan, F. F.; Astuti, E.; Suryanti, V.; Putri, D. E. K.; Nur, H.; Wahyuningsih, T. D. Synthesis of Furan-Based Pyrazoline as an Anticancer Agent: An in Vitro and in Silico Approach toward COX-2 Inhibition. J. Mol. Struct. 2025, 1337. https://doi.org/10.1016/j.molstruc.2025.142125. (3) Rusydi, I. D.; Kartini, I.; Setyawati, A.; Astuti, E.; Wahyuningsih, T. D. Synthesis of N-Phenylpyrazoline Derivative from 2-Acetylfuran and Its Activity as Cu2+ Ion Fluorescent Chemosensor. In AIP Conference Proceedings; A., F., A.A., D., D.T., U., F.I., F., I., Y., F., R., L., A., R., Y., Eds.; American Institute of Physics: Department of Chemistry, Faculty Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia, 2025; Vol. 3248. https://doi.org/10.1063/5.0236842. (4) Haryadi, W.; Gurning, K.; Fachiroh, J.; Astuti, E. Potential of Bioactive Compounds In Coleus Amboinicus, Lour., Leaves Against Breast Cancer By Assessment Using A Network Pharmacology Approach and Cytotoxic Test. J. Multidiscip. Appl. Nat. Sci. 2025, 5 (1), 267–287. https://doi.org/10.47352/jmans.2774-3047.246. (5) Mustika, C. R.; Astuti, E.; Mardjan, M. I. D. Molecular Docking, Synthesis and In Vitro Antiplasmodium Assay of Monoketone Curcumin Analogous from 2-Chlorobenzaldehyde. Indones. J. Chem. 2024, 24 (3), 638–651. https://doi.org/10.22146/ijc.81122. (6) Chunaifah, I.; Venilita, R. E.; Tjitda, P. J. P.; Astuti, E.; Wahyuningsih, T. D. Thiophene-Based N-Phenyl Pyrazolines: Synthesis, Anticancer Activity, Molecular Docking and ADME Study. J. Appl. Pharm. Sci. 2024, 14 (4), 63–71. https://doi.org/10.7324/JAPS.2024.146832. (7) Haryadi, W.; Gurning, K.; Astuti, E. Molecular Target Identification of Two Coleus Amboinicus Leaf Isolates toward Lung Cancer Using a Bioinformatic Approach and Molecular Docking-Based Assessment. J. Appl. Pharm. Sci. 2024, 14 (5), 203–210. https://doi.org/10.7324/JAPS.2024.164753. (8) Wulan, F. F.; Wahyuningsih, T. D.; Astuti, E.; Prasetyo, N. Towards Targeting EGFR and COX-2 Inhibitors: Comprehensive Computational Studies on the Role of Chlorine Group in Novel Thienyl-Pyrazoline Derivative. J. Biomol. Struct. Dyn. 2024, 42 (19), 9857–9872. https://doi.org/10.1080/07391102.2023.2252915. (9) Gurning, K.; Suratno, S.; Astuti, E.; Haryadi, W. Untargeted LC/HRMS Metabolomics Analysis and Anticancer Activity Assay on MCF-7 and A549 Cells from Coleus Amboinicus Lour Leaf Extract. Iran. J. Pharm. Res. 2024, 23 (1). https://doi.org/10.5812/ijpr-143494. (10) Oktriawan, T.; Ariefta, N. R.; Raharjo, T. J.; Astuti, E.; Koseki, T.; Shiono, Y. Phytotoxic and Cytotoxic Polyketides Produced by Fungal Endophytes Isolated from Psidium Guajava. HAYATI J. Biosci. 2023, 30 (3), 473–479. https://doi.org/10.4308/hjb.30.3.473-479. (11) Wahyuningsih, T. D.; Suma, A. A. T.; Stansyah, Y. M.; Astuti, E. Synthesis, Biological Evaluation and Molecular Docking of Methoxy n-Phenylpyrazoline Derivatives as Anticancer Agents. Pak. J. Pharm. Sci. 2022, 35 (4), 965–972. https://doi.org/10.36721/PJPS.2022.35.4.REG.965-972.1. (12) Ramadhan, M. F.; Astuti, E.; Swasono, R. T. Screening and Toxicity Assay of Bioactive Compounds from Ethyl Acetate Extract of Indonesian Marine Sponge Dysidia Sp. from Hoga Island. In Materials Science Forum; Trans Tech Publications Ltd: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21, Yogyakarta, 55281, Indonesia, 2022; Vol. 1061, pp 165–171. https://doi.org/10.4028/p-rg4242. 2015 |